{"id":1726,"date":"2025-06-18T17:11:35","date_gmt":"2025-06-18T14:11:35","guid":{"rendered":"https:\/\/www.humanremodelling.gr\/?p=1726"},"modified":"2025-07-30T14:17:15","modified_gmt":"2025-07-30T11:17:15","slug":"inotiki-antidrasi-se-enesima-emfytevmata-yalouronikou-oxeos-sto-prosopo","status":"publish","type":"post","link":"https:\/\/www.humanremodelling.gr\/en\/inotiki-antidrasi-se-enesima-emfytevmata-yalouronikou-oxeos-sto-prosopo\/","title":{"rendered":"Fibrotic reaction to hyaluronic acid injectable implants in the face"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\"><strong>Background<\/strong><\/h4>\n\n\n\n<p>Hyaluronic acids (HA) can have very different effects, which depend not only on the physician and the patient\u2019s body, but also on their molecular weight.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Short-chain HA exhibits immunological activity.<\/li>\n\n\n\n<li>Long-chain HA affects fibroblasts and may stimulate them to produce collagen.<\/li>\n<\/ul>\n\n\n\n<p>Although this is usually considered positive, it can be unfavorable in certain anatomical areas.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Patients and Method<\/strong><\/h4>\n\n\n\n<p>We treated 23 patients who developed fibrosis next to the nasolabial folds, which:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Accentuated the folds<\/li>\n\n\n\n<li>Became very noticeable when smiling<\/li>\n<\/ul>\n\n\n\n<p>Injection of hyaluronidase did not reduce this mass.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Results<\/strong><\/h4>\n\n\n\n<p>Intralesional injection of triamcinolone acetonide led to rapid improvement.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Discussion<\/strong><\/h4>\n\n\n\n<p>Fibrotic tissue reaction, which does not respond to hyaluronidase, can be a complication of hyaluronic acid injection.<\/p>\n\n\n\n<p>This condition can be effectively treated with intralesional corticosteroid injection.<\/p>\n\n\n\n<p><strong>You can read the full article by Dr. Peros in the Wiley Online Library <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16419\" target=\"_blank\" rel=\"noreferrer noopener\">here<\/a><\/strong><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background Hyaluronic acids (HA) can have very different effects, which depend not only on the physician and the patient\u2019s body, but also on their molecular &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"Fibrotic reaction to hyaluronic acid injectable implants in the face\" class=\"read-more button\" href=\"https:\/\/www.humanremodelling.gr\/en\/inotiki-antidrasi-se-enesima-emfytevmata-yalouronikou-oxeos-sto-prosopo\/#more-1726\" aria-label=\"Read more about Fibrotic reaction to hyaluronic acid injectable implants in the face\">READ MORE<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[33],"tags":[],"class_list":["post-1726","post","type-post","status-publish","format-standard","hentry","category-uncategorized","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-33"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fibrotic reaction to hyaluronic acid injectable implants in the face - HUMAN REMODELLING MEDICAL<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humanremodelling.gr\/en\/inotiki-antidrasi-se-enesima-emfytevmata-yalouronikou-oxeos-sto-prosopo\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fibrotic reaction to hyaluronic acid injectable implants in the face - HUMAN REMODELLING MEDICAL\" \/>\n<meta property=\"og:description\" content=\"Background Hyaluronic acids (HA) can have very different effects, which depend not only on the physician and the patient\u2019s body, but also on their molecular ... READ MORE\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humanremodelling.gr\/en\/inotiki-antidrasi-se-enesima-emfytevmata-yalouronikou-oxeos-sto-prosopo\/\" \/>\n<meta property=\"og:site_name\" content=\"HUMAN REMODELLING MEDICAL\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-18T14:11:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-30T11:17:15+00:00\" \/>\n<meta name=\"author\" content=\"n t\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"n t\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.humanremodelling.gr\/en\/inotiki-antidrasi-se-enesima-emfytevmata-yalouronikou-oxeos-sto-prosopo\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.humanremodelling.gr\/en\/inotiki-antidrasi-se-enesima-emfytevmata-yalouronikou-oxeos-sto-prosopo\/\"},\"author\":{\"name\":\"n t\",\"@id\":\"https:\/\/www.humanremodelling.gr\/en\/#\/schema\/person\/0f8e91c2162ca524b5eaaeb0bca6d653\"},\"headline\":\"Fibrotic reaction to hyaluronic acid injectable implants in the face\",\"datePublished\":\"2025-06-18T14:11:35+00:00\",\"dateModified\":\"2025-07-30T11:17:15+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.humanremodelling.gr\/en\/inotiki-antidrasi-se-enesima-emfytevmata-yalouronikou-oxeos-sto-prosopo\/\"},\"wordCount\":151,\"publisher\":{\"@id\":\"https:\/\/www.humanremodelling.gr\/en\/#organization\"},\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.humanremodelling.gr\/en\/inotiki-antidrasi-se-enesima-emfytevmata-yalouronikou-oxeos-sto-prosopo\/\",\"url\":\"https:\/\/www.humanremodelling.gr\/en\/inotiki-antidrasi-se-enesima-emfytevmata-yalouronikou-oxeos-sto-prosopo\/\",\"name\":\"Fibrotic reaction to hyaluronic acid injectable implants in the face - 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